*Guggul is an Ayurvedic extract sourced from the resin of the Commiphora mukul tree of India. Guggul contains guggulsterones, compounds that maintain healthy lipid metabolism. A 12-week open trial involving guggul supplementation in 205 subjects and a double-blind crossover trial with 125 volunteers receiving guggul demonstrated these effects. In another randomized double-blind study, guggul promoted healthy lipid ratios. In the same study, guggul moderated lipid peroxide levels, revealing important antioxidant action for lipid support. Additional proposed mechanisms for the lipid modulating potential of guggul include supporting liver enzyme and cellular membrane function, promoting receptor function, enhancing bile acid excretion, and promoting thyroid function. In addition, guggulsterones have been shown to support platelet function and fibrinolytic activity, helping to maintain blood vessel health and cardiovascular support. Guggul also shows initial promise for supporting joint function and comfort.